A single amino acid substitution results in a retinoblastoma protein defective in phosphorylation and oncoprotein binding.

 We previously identified a small cell lung cancer cell line (NCI-H209) that expressed an aberrant, subphosphorylated form of the retinoblastoma protein RB1. Molecular analysis of RB1 mRNA from this cell line showed a

mutation at exon 21 that led to a non-conservative amino acid substitution (cysteine ​​to phenylalanine) at codon 706. Strong expression of mutant RB1 cDNA in the human cell line - endogenous RB1 deficiency was demonstrated.

 that this amino acid change is sufficient to inhibit phosphorylation. In addition, this substitution of cysteine ​​for phenylalanine also resulted in the loss of RB1-binding monkey 40 large tumor virus and E1A-modifying egg protein adenovirus. 

These results confirm the importance of the sequences encoding exon 21 and suggest that the cysteine ​​residue at codon 706 may play a role in meeting the specific protein adaptation requirement for protein-protein interactions. .

The Gmail API returns two levels of error information:

HTTP error codes and messages in the header.

A JSON object in the response body with  Gmail Numeric Code 6922 issue additional details that can help you determine how to handle the error.

Gmail apps should catch and handle all errors that might be encountered when using the REST API. This guide provides instructions on how to resolve specific API errors.

Resolve a 400 error: Bad request

This error might result from these errors your code:

A required field or parameter hasn't been provided.

The value supplied or a combination of provided fields is invalid.

Invalid attachment.

Note: This list is not exhaustive, other cases can cause a 400 error.

Following is a sample JSON representation of this error:

r queries with fullText terms. Results are always in descending relevance order."

To fix this error, check the message field and adjust your code accordingly.

Resolve a 401 error: Invalid credentials

A 401 error indicates that the access token you're using is either expired or invalid. This error can also be caused by missing authorization for the requested scopes. Following is the JSON representation of this error:

To fix this error, refresh the access token using the long-lived refresh token. If you are using a client library, it automatically handles token refresh. If this fails, direct the user through the OAuth flow, as described in Authorizing your App with Gmail.

For additional information on Gmail limits, refer to Usage limits.

Resolve a 403 error: Usage limit exceeded

An error 403 occurs when a usage limit has been exceeded or the user doesn't have the correct privileges. To determine the specific type of error, evaluate the reason field of the returned JSON. This error occurs for the following situations:

The daily limit was exceeded.

The user rate limit was exceeded.

The project rate limit was exceeded.

Your app can't be used within the authenticated user's domain.

For additional information on Gmail limits, refer to Usage limits.